[LT-05]
The Longitudinal Research Problem
Longitudinal clinical research operates on a fundamental tension: participants' identities must be protected throughout the study period to satisfy IRB requirements and maintain participant trust, but the same participants may need to be contacted for clinical follow-up if the research reveals unexpected findings.
An oncology research center conducting a 5,000-patient biomarker study discovers mid-study that 47 participants show markers suggesting elevated...